Trazodone for Cats: Overview, Dosage & Side Effects

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A cat in a carrier, a common method for safe transport of feline companions during travel or veterinary visits.

Trazodone is a sedative medication that is often used in cats to help reduce situational anxiety and stress. In this article, you’ll read about trazodone for cats: what it is, how it works, indications for its use, side effects to look for, and some frequently asked questions.

Trazodone for Cats Overview

Medication Type:
Serotonin antagonist/reuptake inhibitor sedative/anxiety relief medication
Oral tablets
Prescription Required?:
FDA Approved?:
Brand Names:
Common Names:
Available Dosages:
Oral tablets in 50mg, 100mg, 150mg, and 300mg size.
Expiration Range:
Products should be used before the expiration on the package. Trazodone should be stored between 20 and 25 degrees C (68-77 degrees F) with excursions of 5 degrees C or about 10 degrees F permitted. Trazodone should be kept in an airtight container and protected from light.

About Trazodone for Cats

A cat during a veterinary examination, highlighting the importance of regular check-ups and healthcare for feline companions.

For many cats, a trip to the vet can induce unhealthy amounts of stress and anxiety.

Trazodone is classified as a serotonin antagonist (5-HT2A) reuptake inhibitor. This means it is a type of antidepressant medication.

Trazodone is not a federally scheduled or controlled medication in the United States. It is still considered a drug of interest in some jurisdictions that requires some additional monitoring by veterinary care providers.

It is generally utilized for more short-term use benefits, usually related to behavioral problems and situational stress or anxiety. Examples of typical feline stressors include visits to the veterinary clinic, hospital stays, and car or plane travel.

While trazodone is more often used in dogs, there have been studies in cats that have shown it to be a viable option for cats.

Trazodone may be used alongside other medications in dogs as long-term medication for anxiety and other behavioral disorders. However, this is not a common indication of its use in cats.

Also Read: Best Large Cat Carriers For Travel Reviewed

What Does Trazodone Do for Cats?

A cat in a car, emphasizing the need for safe and secure transportation when traveling with feline companions.

Most cats view travel by car or plane to be a hugely stressful event.

While trazodone use in dogs has been far more extensively studied, there have been some studies in cats. These studies suggest trazodone is an effective sedative that can be safely administered to stressed cats to remove symptoms of anxiety.

Another study looked at trazodone use in cats during echocardiograms (heart sonograms). It showed that trazodone lowered blood pressure in healthy cats but led to no alterations in the results for the echocardiograms. Since we know that cats often have elevated blood pressure during exams and procedures, this finding suggests that anxiety during handling was reduced without significant effects on the heart.

In a placebo-controlled study published in the Journal of the American Veterinary Medical Association (JAVMA) in 2016, 10 cats with a history of anxiety during travel/transport and/or vet exams were given trazodone 60-90 minutes prior to a visit or instance of travel. In this study, not a single cat displayed signs of anxiety related to the travel or examination and stress scores were significantly better.

As many kitty parents are aware, gabapentin is often used to reduce a cat’s anxiety or stress. Although it works very differently, trazodone has similar effects. Trazodone and gabapentin can be used together for cats that need both medications to help with stress, anxiety, or handling.

Also Read: 5 Visual Signs Of A Stressed Cat And How To Help

Common Side Effects of Trazodone for Cats

A cat in a car, highlighting the importance of safe and comfortable travel arrangements for feline companions.

Trazodone is considered a sedative and it makes cats drowsy.

Trazodone is tolerated in most patients. As it is used most often as a sedative, this is an expected effect to see.

In the JAVMA study involving 10 cats, the most commonly reported potential side effects in cats included (other than sedation): vomiting, gagging, diarrhea, hypersalivation (excessive drooling), paradoxical excitement, behavioral disinhibition, and ataxia (unbalanced walking).

Gagging and excessive drooling are common responses to the bitter taste of medication and the act of tablet administration.

Paradoxical excitement and behavioral disinhibition describe unexpected behavioral effects. In this case, the calm behavior and sedation effects are what is expected. However, excitement, agitation, irritation, and aggression paradoxically happen instead. This is an uncommon side-effect of sedatives but can occur with any type of sedative or anxiety relief medication.

Ataxia or wobbly, unbalanced walking, is a more common side effect of sedatives. This happens more commonly when a cat is drowsy from the medication. It should wear off with the sedative effects.

Uncommon Side Effects of Trazodone for Cats

Because trazodone is classified as an antidepressant and acts as a serotonin reuptake inhibitor, it can contribute to a side effect called serotonin syndrome where serotonin levels become too high in the body.

Common signs of serotonin syndrome include vomiting, diarrhea, seizures, elevated body temperature, depression, hypersalivation, difficulty breathing, disorientation, coma, and sometimes death.

Fortunately, trazodone is very unlikely to cause serotonin syndrome at typical dosages, but caution must be used if using trazodone alongside certain other drugs.

Some of these common drug interactions are included below but are not limited to just what is listed. It’s always important to make your veterinarian fully aware of any medications your cat is currently on before considering trazodone.

Concurrent use with cisapride (a medication used for recurrent constipation in cats), as well as fluoroquinolone antibiotics (pradofloxacin, marbofloxacin), may increase the risk for an arrhythmia called QT prolongation. However, this has unknown implications for pets.

Using trazodone with furosemide (Lasix) may increase the risk of low sodium levels.

If your cat is taking trazodone with any hypotensive drugs like amlodipine or telmisartan, it may further reduce blood pressure and cause hypotension.

The use of trazodone with the appetite stimulant mirtazapine (Mirataz) can increase the risk for further depression, serotonin syndrome, and QT prolongation.

A cat taking serotonin reuptake inhibitors like fluoxetine (Prozac) alongside trazodone may increase the risk for serotonin syndrome. These drugs are commonly used together but careful monitoring is always recommended.

An increased risk of serotonin syndrome may also occur with concurrent use of tramadol and tricyclic antidepressant medications like amitriptyline.

Also Read: Do Cats Feel Sadness?

Signs of Trazodone Overdose

Signs of a trazodone overdose in cats and dogs include excessive sedation, lethargy, ataxia, and vomiting.

As with many medications, caution should be exercised using trazodone in cats with substantial liver or kidney disease.

If you are ever concerned that your kitty may have developed side effects while using trazodone or if an overdose is suspected, make sure to contact your veterinarian, the ASPCA Animal Poison Control Center (1-888-426-4435), or Pet Poison Helpline (1-855-764-7661) immediately for further advice.

Also Read: Drug Poisoning In Cats: Causes, Symptoms, & Treatment

Trazodone for Cats Dosage

A cat in a car, illustrating the need for secure and stress-free transportation for feline companions during travel.

Since using trazodone is considered off-label and cats respond differently to dosages, it is best to follow the guidance of your vet.

Trazodone is not FDA-approved for use in cats. Use in cats is considered off-label, which is very common in veterinary medicine. Dosing is often based on studies, clinical experience, and responses in individual patients.

In the 10-cat study from JAVMA, a dose of 50mg per cat (not 50mg per kilogram) was used 60-90 minutes prior to a veterinary visit and a generally good response was seen.

However, in any patient, the effective dose and duration of use of trazodone vary widely. For example, in another study, 100mg was used but it took 2 hours for peak sedation to occur. In this study, the behavior of the cats was not significantly improved.

In another study, when used with about 100mg of gabapentin, a reduced dose of trazodone of about 25 mg, was used.

For this reason, it’s always best to discuss the dosing of trazodone with your vet prior to using it. This is especially true if your cat is already on other medications for stress or anxiety.

Also Read: Homeopathy For Cats: What You Need To Know


A cat in a carrier, a common method for safe and secure transportation of feline companions during travel or visits to the veterinarian.

While traveling or going to the vet may seem trivial to us, to our cats, it can be stressful enough to justify the use of anxiety-reducing medication.

Trazodone is a sedative and anxiety-reducing medication that may be used in cats. It is especially useful for short-term relief of stress and anxiety related to travel or veterinary visits. It appears to be well-tolerated in general. However, it should be used carefully in cats on other medications, especially other anxiety-relief medications.

Drug Dosing Disclaimer: We are only able to provide doses for medications that are FDA approved for use in cats and only as the label guidelines dictate. For medications that are used off-label we can only provide guidelines and safety information for use. Safe and appropriate dosing for off-label medications can only be determined by a primary care veterinarian.

We encourage you to work with your veterinarian to determine if a particular medication is appropriate for your cat. Changing or adjusting a dose for your cat on your own without consulting with a veterinarian can carry risk. We do not encourage use of medications prescribed for human use in pets without first consulting with a primary care veterinarian.

Frequently Asked Questions

How much trazodone can I give my cat?

You should always discuss the dosing of any medication with your veterinarian first, especially if your cat has not been on that medication before. Also avoid using medications prescribed for yourself, your dog, or another pet in the home without discussing it with your vet first. 

In studies involving trazodone use in cats, doses of 25-50mg per cat were used, but the effect can be variable depending on the individual cat as well as other medications being used.

Will trazodone put my cat to sleep?

If by “put to sleep” we’re talking about sedation, then yes, trazodone can help to provide some sedation in cats. It rarely causes excessive sedation when used at common doses in otherwise healthy cats. 

How fast does trazodone work in cats?

In both dogs and cats, the peak onset of the effects of trazodone has a high degree of variability. In the 10-cat JAVMA study referenced in the article, desired effects were observed after 60-90 minutes. In another study, 2 hours was the average onset time, but there was a degree of variability on either end of up to 4 ½ hours. 

Dosing short-acting anxiety and sedative medications in veterinary patients is often based on a trial and error process to determine what dose and elapsed amount of time works best for an individual kitty to help facilitate travel or exam handling.

How much trazodone can I give my 20-pound cat?

Regardless of a cat’s weight or size, many veterinarians advocate still beginning with an average starting dose. In otherwise healthy cats, this has been described most often as a 25-50mg dose of trazodone, but it’s always best to discuss with your vet first what an ideal starting dose for your kitty might be, depending on the indication, your cat’s health status, and other medications your kitty may be taking. 

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About Dr. Chris Vanderhoof, DVM, MPH

Dr. Chris Vanderhoof is a 2013 graduate of the Virginia-Maryland College of Veterinary Medicine (VMCVM) at Virginia Tech, where he also earned a Masters in Public Health. He completed a rotating internship with Red Bank Veterinary Hospital in New Jersey and now works as a general practitioner in the Washington D.C. area. Dr. Vanderhoof is also a copywriter specializing in the animal health field and founder of Paramount Animal Health Writing Solutions, which can be found at Dr. Vanderhoof lives in the Northern Virginia area with his family, including 3 cats.

6 thoughts on “Trazodone for Cats: Overview, Dosage & Side Effects”

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    1. Avatar photoDr. Chris Vanderhoof, DVM, MPH Post author

      Hi Kathy,
      It is common to give trazodone to pets on an SSRI like paroxetine or fluoxetine in the event of an acute stressor, like a vet visit. Giving trazodone and an SSRI together can increase the risk for serotonin syndrome however. Giving the lowest effective dose is ideal to reduce that risk. An alternative would be gabapentin, which does not carry the same risk, so that may be an option worth exploring with your vet.

  1. Claire James

    My vet has prescribed it for helping my cat to sleep at night as she has anxiety, Is the effect of taking Trazadone instant or does it take a few weeks to show the results?

    1. Avatar photoDr. Chris Vanderhoof, DVM, MPH Post author

      Hi Claire,
      Trazodone is a shorter acting sedative. It will usually take effect within about 3 hours of giving it. It is then usually out of the system within 8-12 hours. I hope it helps your kitty to rest.

    1. Avatar photoDr. Chris Vanderhoof, DVM, MPH Post author

      Hi Anthony,
      Gabapentin is a common go-to, but I have found that trazodone works well for some of my patients too. Unfortunately, there is no way to know for sure what sedative will work better for a particular cat if there is no experience with one yet. I’ll usually advise starting with one medication choice and seeing the effect it has at home. If there is a clear sedative effect and no unwanted adverse effects, we can then try it for a stressful event. Under your vet’s guidance, you can see which one they would suggest starting with.