Cat Blood Transfusions: Procedure, Cost, Success Rate, & Recovery

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An image related to cat blood transfusions, emphasizing the medical procedure and importance of this treatment in feline healthcare.

You are likely familiar with the concept of donating blood for human medical patients, but did you know that blood transfusions are also used in the veterinary field? Cats, dogs, and other small animal species can all benefit from blood transfusions when experiencing anemia caused by injury or illness.

Quick Overview: Cat Blood Transfusions

clock Urgency: High
jam-medical Requires Vet Visit: Yes
cat Seen in Cats: Sometimes
link-chain May be Linked to: Incompatability with transfused blood.
pill Treatment Options: Stopping transfusion, intravenous fluids, steroid medication. Other treatments depending on signs and severity.

Cat Blood Transfusion Procedure: How Does it Work?

An image related to a cat's blood test, highlighting the diagnostic process in feline healthcare.

Prior to a blood transfusion, blood testing will allow your veterinarian to ensure that the donor and recipient are a good match.

 The first step in a blood transfusion is pre-transfusion testing. There are a number of tests that are performed prior to a blood transfusion, in order to ensure that the donor and recipient are a match.

First, your veterinarian will probably determine your cat’s blood type.

There are three blood types in the feline blood group system: Type A, Type B, and Type AB. Type A is the most common blood type and it is found in 95% of Domestic Shorthaired cats. Type A blood is also common in Siamese, Burmese, and Russian Blue cats. Type B blood is the predominant blood type in Persians, Abyssinians, Devon Rexes, Scottish Folds, Maine Coons, and Sphinxes. Type AB blood is rare, but can occur in cats of any breed.

There is no “universal donor” in cats.

Cats with Type A blood should only receive blood from a Type A donor and cats with Type B blood should only receive blood from a Type B donor, because cats with Type B blood have anti-A antibodies and cats with Type A blood have anti-B antibodies. Cats with Type AB blood are regarded as “universal recipients,” because they can receive any blood type.

Once your cat’s blood type has been identified and a suitable donor has been found, your veterinarian will perform a test called a cross-match to assess donor/recipient compatibility.

This involves mixing small quantities of your cat’s blood and donor blood, then observing the mixed samples under the microscope.

This test can help identify donor/recipient blood pairings that are associated with a high risk of reactions. In some cases, even two cats of the same blood type will show evidence of reaction on cross-matching. If this occurs, a new donor may need to be identified.

After blood typing and cross-matching, your veterinarian will collect whole blood from the donor cat. (If no suitable in-house donor is available, your veterinarian may obtain blood from a blood bank instead.)

The quantity of blood collected depends on a number of factors, including your cat’s size, the donor cat’s size, and the severity of your cat’s anemia. This blood donation is collected into a special bag or bottle, which contains anticoagulant to prevent clotting of the blood.

After collection, this bag or bottle of blood will be connected to a fluid line, with an in-line filter to remove any blood clots that may have formed despite the anticoagulant. The fluid line will be inserted into an intravenous catheter, placed in your cat’s leg.

Blood transfusions are typically given slowly, over a period of one to three hours. A slow administration rate provides ample opportunity for the veterinary team to monitor your cat and adjust treatment if necessary. After the transfusion, your cat will likely remain hospitalized for at least 24 hours, in order to allow for post-transfusion monitoring.

Why a Cat May Need a Blood Transfusion

An image related to anemia in cats, highlighting a medical condition affecting feline blood health.

Blood transfusions are necessitated by a variety of conditions, including FeLV, FIV, cancer, and kidney disease. Any time that a cat has a significantly low red blood cell count, a blood transfusion may be necessary.

 Cats may require a blood transfusion for a variety of reasons. Any time that a cat experiences a significantly low red blood cell count, a transfusion may be considered. In a healthy cat, the Packed Cell Volume (PCV), or the percentage of the blood that is composed of red blood cells, is 25-45%. Most veterinarians will recommend a blood transfusion when a cat’s PCV falls below 10-15%, although this decision is also influenced by the cat’s clinical appearance.

There are a number of possible reasons that a cat can experience a loss of red blood cells, or a decrease in PCV.

These causes can be thought of in three broad categories: decreased red blood cell production, increased red blood cell loss, or increased red blood cell destruction.

Red blood cells are produced within the bone marrow. Any disease that affects the bone marrow can interfere with the production of red blood cells, leading to anemia. The lifespan of a normal feline red blood cell is only about two months, so without a constant supply of newly-produced red blood cells to replenish dying red blood cells, anemia can and will develop.

Bone Marrow Disease

Cat Lying on White Background Feline Leukemia

Cats with Feline Leukemia become immunocompromised, which may lead to a range of secondary health issues.

Common causes of bone marrow disease in cats include Feline Leukemia Virus (FeLV), Feline Immunodeficiency Virus (FIV), and cancer.

Kidney Disease

Kidney Failure in Cats Symptoms Cat in Litter Box

Excessive thirst and urination are among the most recognizable symptoms of kidney failure in cats.

The kidneys are also involved in triggering the production of red blood cells, so kidney disease may also lead to a decrease in red blood cell production.’


An image related to a cat with a nosebleed, illustrating a medical condition that may require veterinary attention.

Red blood cell loss occurs due to bleeding. While this bleeding may be caused by trauma, anemia is more commonly caused by gradual, chronic blood loss.

Common causes of bleeding in cats include gastrointestinal bleeding (ulcers or bleeding tumors), bleeding tumors elsewhere in the body, severe flea infestation, and blood clotting disorders. Increased bleeding can overcome the body’s ability to create new red blood cells, resulting in anemia.

Immune-Mediated Disease

Cat high blood pressure can cause sneezing blood

High blood pressure may cause cats to sneeze blood or have nosebleeds.

Red blood cell destruction refers to the destruction of red blood cells within the circulation. This destruction is caused by immune-mediated disease, in which the cat’s body begins to recognize its own red blood cells as foreign.

Immune-mediated disease may be caused by a primary autoimmune disease, or may occur in response to another trigger such as cancer, a red blood cell infection, or a drug reaction. Cats with increased red blood cell destruction may become anemic if the rate of red blood cell destruction exceeds the rate of new red blood cell production.

Cat Blood Transfusion Success Rate

An image related to a blood transfusion, emphasizing its importance and role in feline medical care.

A research study performed in 2004 examined the survival rates of 91 cats receiving blood transfusions. In this study, 84% of cats were still alive one day after their transfusion and 64% of cats were still alive 10 days post-transfusion. None of the deaths were attributed to a transfusion reaction; all were a result of the cat’s underlying disease.

Cats requiring a blood transfusion are typically very ill. By the time a cat’s PCV is low enough to require a blood transfusion, the cat is likely to die without that life-saving care. A blood transfusion can dramatically improve the prognosis for a cat with severe underlying disease. However, the impact of a transfusion is largely dependent on the cat’s underlying disease.

A cat who is experiencing life-threatening anemia due to a severe flea infestation will likely have a good prognosis if a blood transfusion is given and appropriate flea treatment is administered.

A cat with cancer affecting the bone marrow, however, may experience brief relief of weakness and lethargy from a blood transfusion, but the cat’s long term survival will depend upon the ability to control the underlying bone marrow cancer.

Reactions to Blood Transfusions

There are two different types of transfusion reactions that can occur in cats: immunologic and non-immunologic.

Immunologic Reactions

An image related to a blood test in cats, highlighting the diagnostic process in feline healthcare.

Immunologic reactions are those reactions that we first think of when we consider transfusion reactions; they involve the body’s immune response to receiving foreign red blood cells and can resemble an allergic reaction.

Nom-Immunologic Reactions

An image related to a blood test in cats, illustrating a diagnostic procedure in feline healthcare.

Non-immunologic reactions, in contrast, are not caused by an immune reaction. Examples of non-immunologic reactions include volume overload (a response to the fluid volume that is administered during a blood transfusion, which can place a strain on the heart and lungs), infectious disease transmission, or bacterial infection due to contaminated blood products.

Most transfusion reactions occur during the first 48 hours after receiving a transfusion.

The signs and severity of these reactions may vary significantly, ranging from a mild allergic reaction to a more severe anaphylactic reaction.

Signs of an Adverse Reaction to a Blood Transfusion

An image related to cat bloodwork, emphasizing the importance of blood tests in feline healthcare.

The most common clinical sign of a transfusion reaction is a fever, which indicates an immune response to the foreign red blood cells. In some circumstances, this reaction may progress to include hives, skin inflammation, itching, vomiting, and/or diarrhea. Pale gums may also develop, in addition to an elevated heart rate and/or respiratory rate. If signs of a transfusion reaction are noticed during a blood transfusion, your veterinarian will immediately stop the transfusion.

In some cases, an immunologic transfusion reaction may involve the breakdown of the transfused red blood cells. The body’s immune system recognizes these cells as foreign and attacks them, causing breakdown of the red blood cells, or hemolysis.

Cats with a hemolytic reaction may develop icterus, also known as jaundice. They may develop a yellow discoloration of the gums or the whites of the eyes, caused by red blood cell breakdown products.

Regardless of whether the reaction occurs during or after the transfusion, your veterinarian will administer treatments to halt the reaction.

These treatments may include antihistamines, corticosteroids, and/or epinephrine, depending on the severity of the reaction. Your cat may also require intravenous fluids, to help support circulation and maintain blood pressure.

These treatments may be short-lived, or your cat may be discharged on a prolonged course of immunosuppressive drugs to prevent further reactions until the red blood cells have served their purpose and been cleared from circulation.

It’s important to note that most transfusion reactions can be corrected with medical care. While life-threatening reactions can occur, the 2004 feline transfusion study did not find any evidence of life-threatening transfusion reactions in the 91 cats included in the study.

Veterinarians carefully balance the risks and benefits of blood transfusions, only recommending them for those cats in which the risk of untreated anemia exceeds the risk of a significant transfusion reaction.

Recovering From a Blood Transfusion

Recovering from a blood transfusion

Most cats will show almost immediate improvement after a blood transfusion. Recovery time and appropriate care depends on the condition that necessitated the transfusion.

Recovery from a blood transfusion depends largely on the underlying disease responsible for the anemia. In most cases, you will notice an immediate improvement in your cat’s condition after the blood transfusion, because restoring normal numbers of red blood cells will improve your cat’s oxygen circulation and overall energy levels.

Post-transfusion care will depend on your cat’s underlying condition. Your veterinarian may prescribe antibiotics to treat an underlying infection, or corticosteroids if your cat has an immune-mediated disease. Your cat may also need to wear an e-collar (cone) if there are wounds or sutures that your cat may traumatize.

Cat Blood Transfusion Cost

An image related to cat blood test work, highlighting the diagnostic process in feline healthcare.

 The cost of a feline blood transfusion may vary significantly, depending on the cat’s overall condition, the volume and quantity of transfusions that are required, and the side effects that may or may not develop.

Most feline blood transfusions are performed at specialty hospitals, in order to ensure that cats receiving a transfusion can receive necessary 24-hour monitoring. The cost of a feline blood transfusion may range from $500-2,000, although costs may be even higher in critically ill cats or those that experience complications associated with their blood transfusion.

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Causes of high blood pressure in cats

Blood transfusions can be a life-saving treatment for cats with severe anemia. Although the procedure is not entirely risk-free, appropriate pre-transfusion testing can help minimize risk while still providing maximal benefits for anemic cats.

Frequently Asked Questions

Can cats have blood transfusions?

In cats with severe anemia, blood transfusion can be a life-saving procedure. These transfusions are administered similarly to blood transfusions in humans; the same basic principles of transfusion medicine apply, although there are differences in blood types.

Where do they get blood for cat transfusions?

Most feline blood transfusions involve the use of blood collected from a donor cat. Blood substitutes, such as Oxyglobin®, are also available and may be used when a blood donor is not available.

How long is a cat blood transfusion?

The duration of a blood transfusion varies, based upon the volume of the transfusion and the cat’s medical condition. In general, most transfusions are given over a period of one to three hours.

What cat blood type is considered the universal donor?

There is no such thing as a universal donor in feline transfusion medicine. Cats naturally develop antibodies against the blood antigens that they lack.

How much does a blood transfusion cost for a cat

The cost of a feline blood transfusion may range from $500-2,000, although costs may be even higher in critically ill cats or those that experience complications associated with their blood transfusion.

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About Dr. Cathy Barnette, DVM

Dr. Barnette is a veterinarian and freelance writer based in Florida. Her 14 years of experience in small animal clinical practice have allowed her to witness firsthand the communication gaps that often exist between pet owners and members of the veterinary team. Her goal is to create engaging content that educates owners, empowering them to make the best possible decisions for their pets. Dr. Barnette has two cats of her own, in addition to a dog and a pet dove.

9 thoughts on “Cat Blood Transfusions: Procedure, Cost, Success Rate, & Recovery”

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  1. D

    Hi I have a cat that is not 2 old I would say around 4 to 5 years he was pretty healthy and solid and all of a sudden became ill …apparently needs a blood transfusion the vet I have brought him to are saying 3 to 6 thousand dollars I have noticed the price you have said in this is a lot lower I’m just wondering if how it could be so much for the same thing any ideas ???? Have you heard of it being this crazy amount

    1. M H

      Every vet in my local area of California far exceeds the averages stated anywhere on the internet. Not sure what state you are in, but it’s the case for many other services and products too.

  2. sandra

    I wish we have some options and some better prices. We are trying to save our fur babies. Check your veterinary school in you state.

  3. Surujdai Pachai

    It is so sad to know my baby needs a blood transfusion and it is so expensive 5thousand 2hundred dollars.
    Veterans need to help in some way to assist in price for your pet that play a big part in your live.thank you.

  4. Agnes

    This is price gouging! My cat JUST got a transfusion at one of the big groups of Veterinary Emergency (VEG) and the whole ER visit, transfusion plus a full night of hospitalization went down to about $2000 which is consistent with the article; so FIVE to SIX thousand???? This is despicable price gouging from your vet and it is even criminal because animals get killed over estimates like that so this is deeply unethical and should be reported as such. Can you name names so that people know where NOT to go if their pet needs help?
    Let’s remember that vets take an oath to do what is best for the animals. Let’s also remember that vets complain left and right that there is a high rate of suicide in their profession but I would also want to kill myself if I was one day coming to the realization that so many animals were killed because of my greed and that my brand new Mercedes and an overstaffed office have blood all over them!

  5. Chris

    I was left with the hardest decision in my life they just wanted money 8-10thousand for a blood transfusion or your only family member will not be around I didn’t have the money wasn’t allowed to go on a payment plan and was left to make the most heart breaking decision in my life I have never felt loneliness until the second I had to make the most ultimate decision of both our lives I had not cried this much when my mom died now I’m left with a big hole in my heart and I’m t to blame myself for not being able to afford to get a transfusion for the only one that made me get up every morning I love you orangie my baby I miss you